By Steven Clarke (auth.), Ronald T. Borchardt, Cyrus R. Creveling, Per Magne Ueland (eds.)
This ebook has been constructed from its prior and much much less formal presentment because the complaints of a symposium entitled The Biochemistry of S-Adenosylmethionine as a foundation for Drug layout that was once held on the Solstrand Fjord inn in Bergen, Norway on June 30-July four, 1985. the aim of the symposium used to be to compile scientists from a variety of disciplines (biochemistry, pharmacology, virology, immunology, chemistry, drugs, etc) to debate the new advances which have been made in our realizing of the organic roles of S adenosylmethionine (AdoMet) and to debate the feasibility of using AdoMet-dependent enzymes as objectives for drug layout. therefore the knowledge supplied herein might be of worth not just to easy scientists interested in elucidating the function of AdoMet in biology, but additionally to medicinal chemists who're utilizing this easy wisdom within the technique of drug layout. the quantity must also be of curiosity to pharmacologists and clinicians fascinated about organic assessment of power healing brokers bobbing up from the efforts of the biochemists and medicinal chemists. each one plenary speaker on the symposium used to be asked to publish a bankruptcy reviewing fresh contributions in their self-discipline to our base of information in regards to the organic function of AdoMet. issues lined during this quantity comprise protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the law of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), medical elements of AdoMet (Section D), and the layout, synthesis, and organic evaluate of trans methylation inhibitors (Section E).
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Additional info for Biological Methylation and Drug Design: Experimental and Clinical Role of S-Adenosylmethionine
Acta 622, 144. Kim, S. (1974) Arch. Biochem. Biophys. 161, 652. , Chin, W. and Paik, W. K. (1978) Anal. Biochem. 84, 415. , Campagnoni, A. T. and Paik, W. K. (1984) Biochem. Biophys. Res. Communs. 123, 468. Kleene, S. , Toews, M. L. and Adler, J. (1977) J. Biol. Chern. 252, 3214. Lee, H. , Kim, S. and Paik, W. K. , 78. Paik, W. K. and Kim, S. (1970) J. Biol. Chern. 245, 6010. Paik, W. K. and Kim, S. (1980) Protein Methylation, John Wiley & Sons, New York. Paik, W. K. and Kim, S. (1985) The Enzymology of Post-Translational Modification of Proteins, Vol.
1985 for references). We have shown that methylaccepting chemotaxis proteins of Bacillus subtilis and of Spirochaeta aurantia exhibit distinct homologies with the transducers of E. , 1985). The 3xperiments involved direct immunoprecipitation of methylH-labeled proteins from those species by antiserum raised to a transducer from E. col i as well as comparison of methylated tryptic peptTdes by high-pressure liquid chromatography. The observations imply that methyl-accepting proteins in the three contemporary species were derived from a protein that was contained in the common ancestor of these distantly related bacteria.
Biophys. Acta 622, 144. Kim, S. (1974) Arch. Biochem. Biophys. 161, 652. , Chin, W. and Paik, W. K. (1978) Anal. Biochem. 84, 415. , Campagnoni, A. T. and Paik, W. K. (1984) Biochem. Biophys. Res. Communs. 123, 468. Kleene, S. , Toews, M. L. and Adler, J. (1977) J. Biol. Chern. 252, 3214. Lee, H. , Kim, S. and Paik, W. K. , 78. Paik, W. K. and Kim, S. (1970) J. Biol. Chern. 245, 6010. Paik, W. K. and Kim, S. (1980) Protein Methylation, John Wiley & Sons, New York. Paik, W. K. and Kim, S. (1985) The Enzymology of Post-Translational Modification of Proteins, Vol.