By P. Gopinath, S. Uday Kumar, Ishita Matai, Bharat Bhushan, Deepika Malwal, Abhay Sachdev, Poornima Dubey
This short offers a transparent perception of the new advances within the box of melanoma theranostics with distinct emphasis upon nano scale provider molecules (polymeric, protein and lipid established) and imaging brokers (organic and inorganic).
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Extra resources for Cancer Nanotheranostics
5 Protein Based Nanoparticles: Introduction Successful cancer treatment depends on early, non-invasive and accurate diagnosis in combination with specific treatment procedures. Current diagnosis and therapeutic techniques need to be improved in order to achieve earlier detection abilities, enhanced therapeutic potential and cell specific targeting. This portion emphasized the current advances in field of protein based multifunctional nanoplatforms for targeted cancer detection and therapy, as well as the major outcomes of the in vitro and in vivo investigations.
2011) synthesized a Janus-like multifunctional dendrimer comprising of 9 azide termini, 9 amine termini and 54 terminal acid groups as next generation of materials for cancer theranostics. Dendrimers can also be linked to other nanomaterials such as carbon nanotubes (CNTs) to improve the drug loading capacity and achieve targeted delivery to cancer cells. In one such attempt, Wen et al. (2013) designed PAMAM G5/FA/FI (fluorescein isothiocyanate)—multiwalled carbon nanotubes (MWCNTs) for targeted and pH responsive delivery of DOX to KB cells over expressing folic acid receptors (FAR).
PPEI-EI passivated C-dots were found to be strongly emissive under fluorescence microscope following excitation by 800 nm laser. The cellular uptake of C-dots was restricted to the cell membrane and the cytoplasm of MCF-7 cells, without any evidence of nuclear labelling (Cao et al. 2007). In order to explore the effect of surface passivation on cellular uptake of C-dots, these were passivated by two kinds of polymers, including PEG and PEI. Fluorescence microscopy images showed that PEI functionalized C-dots were more efficiently internalized inside A549 and BHK-21 cell lines than PEG functionalized C-dots.